We have tuned a few Vettes with the vararam setup, it should not require any changes to the tune until you make some more mods to improve breathing like headers or a cam.
The provided tune will make a noticable difference in performance in the C6 Vette.

Thanks

Thanks for the quick reply Mike. I ...

I have a 2007 Z51 6 spd Manual Corvette. Bone stock except for the addition of a Vararam Snake Charmer ram air package. Have purchased a U7194 Diablo Sport Predator Power Programmer and now need to know how best to take advantage of this combination.

Also, in a few weeks I will also install the ...