How to tune for LT headers?

[BlackNTan]

U7151
v.9r08
2007, Ford F150 SCrew 5.4L 3V.
Dual exhaust (southern comfort pkg)
Spectre 4" CAI

previous adventure here: http://diablosport.com/index.php?name=P ... ic&t=22618

I've previously installed a spectre CAI and got it tuned to that setup; Now, if I were to install some LT headers such as OBX or Dynatech...how would that affect the tune? Would I need a custom tune at that point, or can I use the predator to compensate? What should I expect?